Posterior insular cortex is necessary for conditioned inhibition of fear

Allison R. Foilb, Johanna G. Flyer-Adams,Steven F. Maier,John P. Christianson

Neurobiology of Learning and Memory（2016）

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摘要

•NMDAR blockade of posterior IC prevented acquisition of conditioned inhibition.•After extensive CS+/CS− conditioning, posterior IC inhibition reduced fear recall.•Manipulations to posterior IC had no effect on fear discrimination.

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关键词

Rat,Fear,Insula,Inhibition,Plasticity

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