Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α

Beatrice Macchi,Emanuela Balestrieri,Caterina Frezza,Sandro Grelli,Elena Valletta,Ambroise Marçais,Francesca Marino-Merlo,Jocelyn Turpin,Charles R Bangham,Olivier Hermine,Antonio Mastino,Ali Bazarbachi

Blood Advances（2017）

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摘要

The therapeutic efficacy of the AZT and IFN combination in ATL presumably reflects the inhibition of RT-related functions.HTLV-1-RT activity from short-term cultured PBMCs may represent a predictive correlate of clinical response to AZT/IFN in ATL patients.

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transcriptase activity,zidovudine,atl patients

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