JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics

Thomas McKerrell,Naomi Park,Jianxiang Chi,Grace Collord,Thaidy Moreno,Hannes Ponstingl,Joao Dias,Petroula Gerasimou, Kiki Melanthiou,Chrystalla Prokopiou,Marios Antoniades,Ignacio Varela,Paul A. Costeas,George S. Vassiliou

Blood Advances（2017）

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摘要

TO THE EDITOR: The JAK2 V617F mutation is the most common somatic mutation in the classical myeloproliferative neoplasms (MPNs), present in >95% of cases of polycythemia vera (PV) and ∼50% of essential thrombocythemia (ET) and myelofibrosis (MF).[1][1][⇓][2][⇓][3]-[4][4] It is usually the

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