Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Joana Carrelha,Yiran Meng,Laura M. Kettyle,Tiago C. Luis,Ruggiero Norfo,Verónica Alcolea,Hanane Boukarabila,Francesca Grasso,Adriana Gambardella,Amit Grover,Kari Högstrand,Allegra M. Lord,Alejandra Sanjuan-Pla,Petter S. Woll,Claus Nerlov,Sten Eirik W. Jacobsen

NATURE（2018）

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摘要

nalysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

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关键词

stem,cells,multipotent,lineage-restricted

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