An improved synthesis of 1-methylcyclopropanol using the Kulinkovich reaction.

Bioorganic & Medicinal Chemistry(2018)

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摘要
An improved process for the preparation of 1-methylcyclopropanol using the Kulinkovich reaction is described. The use of titanium tetramethoxide as catalyst resulted in minimal side product formation. The reaction, isolation and purification procedures were optimized so they can be easily implemented in multi-purpose equipment.
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关键词
Kulinkovich,Titanium tetramethoxide,Scalable,Grignard
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