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Impact of HPMC on inhibiting crystallization and improving permeability of curcumin amorphous solid dispersions.

Na Fan,Zhonggui He,Pingping Ma,Xin Wang,Chang Li,Jin Sun,Yinghua Sun,Jing Li

Carbohydrate Polymers（2018）

Cited 51|Views25
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Abstract
•HPMC inhibited Cur crystallization by forming hydrogen bond with drug in ASDs.•HPMC improved membrane permeability by lowering order level of phospholipid bilayer.•Cur-E100/HPMC 6:1 was superior in improving dissolution and permeability of Cur.
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Key words
Curcumin amorphous solid dispersions,Inhibit crystallization,Improve permeability,Hydrogen bonding,Ionic interactions
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