Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology.

OPEN FORUM INFECTIOUS DISEASES(2017)

Cited 13|Views17
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Abstract
The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.
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Key words
case-fatality rate,complement,hantavirus,Puumala virus,vascular leakage
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