Metal-organic framework-derived three-dimensional porous Cu@graphitic octahedron carbon cages as highly efficient enrichment material for simultaneous determination of four fluoroquinolones.

•The porous Cu@graphitic octahedral carbon cages as adsorbent was fabricated.•3D-Cu@graphitic carbon cages exhibited high extraction efficiency for four FQs.•A new strategy for separating four FQs was obtained by 3D carbon cages.•The method showed a good linearity, low LOD and satisfactory recovery.•The method was satisfactorily applied to analyze four FQs from real samples.