Loss Of 5-Hydroxymethylcytosine Is A Frequent Event In Peripheral T-Cell Lymphomas

Francois Lemonnier,Elsa Poullot,Aurelie Dupuy,Lucile Couronne,Nadine Martin,Laurianne Scourzic,Virginie Fataccioli,Julie Bruneau,Rob A. Cairns, Tak W. Mak,Olivier A. Bernard,Laurence De Leval,Philippe Gaulard

HAEMATOLOGICA（2018）

Cited 22|Views3

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Abstract

Mutations in the epigenetic regulators TET2, IDH2 , and DNMT3A are frequent in peripheral T-cell lymphomas (PTCL), especially in those derived from T follicular helper (TFH) cells. However, the consequences of these alterations on overall levels of 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine

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