Evolution of a designed protein assembly encapsulating its own RNA genome

Gabriel L. Butterfield,Marc J. Lajoie,Heather H. Gustafson,Drew L. Sellers,Una Nattermann,Daniel Ellis,Jacob B. Bale, Sharon Ke,Garreck H. Lenz, Angelica Yehdego,Rashmi Ravichandran,Suzie H. Pun,Neil P. King,David Baker

NATURE（2017）

引用 209|浏览41

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摘要

Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

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关键词

Experimental evolution,Nanoparticles,Synthetic biology,Viral evolution,Science,Humanities and Social Sciences,multidisciplinary

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