Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.

Naoki Kaneko,Shintaro Kawano,Kaori Yasuda,Yuma Hashiguchi,Taiki Sakamoto,Ryota Matsubara,Yuichi Goto,Teppei Jinno,Yasuyuki Maruse,Masahiko Morioka,Taichi Hattori,Shoichi Tanaka,Hideaki Tanaka,Tamotsu Kiyoshima,Seiji Nakamura

Oral Oncology（2017）

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摘要

•ΔNp63β positively regulates KLK6 and PAR2, and negatively regulates PAR1 in OSCC.•Up-regulates KLK6-PAR2 and down-regulates PAR1 induces malignant transformation.•Down-regulates KLK6-PAR2 and up-regulates PAR1 lead EMT.•KLK6 has two different roles in malignant transformation and EMT in OSCC.•KLK6 has potential of biomarker and therapeutic target for OSCC.

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关键词

Oral cancer,Kallikrein-related peptidase 6,Malignant transformation,Epithelial-to-mesenchymal transition (EMT),ΔNp63,Oral squamous cell carcinoma (OSCC),Protease-activated receptor,Metastasis,Prognosis

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