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An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

Xiao-Jing Zhang,Xu Cheng,Zhen-Zhen Yan,Jing Fang,Xiaozhan Wang,Weijun Wang, Zhen-Yu Liu,Li-Jun Shen,Peng Zhang,Pi-Xiao Wang,Rufang Liao,Yan-Xiao Ji,Jun-Yong Wang,Song Tian,Xue-Yong Zhu,Yan Zhang,Rui-Feng Tian,Lin Wang,Xin-Liang Ma,Zan Huang,Zhi-Gang She,Hongliang Li

NATURE MEDICINE（2017）

Cited 202|Views59
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Abstract
LOX12-mediated generation of 12-HETE leads to GPR31 activation and liver injury in ischemia–reperfusion, which can be targeted in a nonhuman primate model to improve outcome.
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Key words
Liver diseases,Pathogenesis,Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences
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