Comparison of Quantification Algorithms for Circulating Cell-Free DNA Methylation Biomarkers in Blood Plasma from Cancer Patients

Luka de Vos,Heidrun Gevensleben,Andreas Schröck,Alina Franzen,Glen Kristiansen,Friedrich Bootz,Dimo Dietrich

Clinical epigenetics（2017）

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摘要

SHOX2 and SEPT9 methylation in circulating cell-free DNA (ccfDNA) in blood are established powerful and clinically valuable biomarkers for diagnosis, staging, prognosis, and monitoring of cancer patients. The aim of the present study was to evaluate different quantification algorithms (relative quantification, absolute quantification, quasi-digital PCR) with regard to their clinical performance.

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关键词

Free-circulating cell-free DNA,DNA methylation,SHOX2,SEPT9,Diagnostic accuracy,Risk stratification,Quantitative real-time PCR,ΔΔCT-method,ΔCT-method,Quasi-digital PCR

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