Improved separation by at-column dilution in preparative hydrophilic interaction chromatography.

Geoffrey Jaffuel,Laura Chappuis,Davy Guillarme,Ted C J Turlings,Gaétan Glauser

Journal of Chromatography A（2018）

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摘要

•At-column dilution (ACD) was systematically evaluated in preparative HILIC.•The effect of the injection solvent in ACD vs. conventional mode was investigated.•The impact of the ACD make-up flow rate on efficiency was also determined.•ACD considerably reduced peak distortion caused by the injection of strong solvent.•ACD was found to be more suited to gradient vs. isocratic elution.

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关键词

HPLC,Preparative chromatography,HILIC,At-column dilution,Efficiency,Peak capacity

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