Evaluation of the dynamic predictors of fluid responsiveness in dogs receiving goal-directed fluid therapy.

Objectives Goal-directed fluid therapy (GDFT) based on pulse pressure variation (PPV) was used in anaesthetized dogs undergoing abdominal surgeries. The aims were 1) to evaluate the success rate of the PPV >= 13% in detecting fluid responsiveness [delta stroke volume (Delta SV) >= 10%]; 2) to assess the correlation between PPV, systolic pressure variation (SPV), Plethysmograph Variability Index (PVI) and central venous pressure (CVP) and 3) to establish the threshold value for the PVI that would predict a PPV value of >= 13% and indirectly discriminate responders from nonresponders to fluid therapy. Study design Clinical, prospective, interventional study. Animals A total of 63 client-owned dogs scheduled for abdominal procedures. Methods PPV and SPV were calculated manually from the invasive blood pressure trace on the Datex monitor. PVI was recorded from the Masimo pulse oximeter. Fluid challenge (10 mL kg(-1) Compound Sodium Lactate) was performed when PPV was >= 13% and/or mean arterial pressure (MAP) < 60 mmHg. Fluid responsiveness was assessed by the transoesophageal Doppler probe. Cardiovascular parameters (heart rate, MAP, PPV, SPV, PVI, SV and if available, CVP) were measured before and after each fluid intervention. Results PPV >= 13% reliably predicted fluid responsiveness in 82.9% of cases. There was positive correlation between PPV and SPV (r = 0.84%), PPV and logPVl (r = 0.46) as well as SPV and logPVl (r = 0.45). Noninvasive PVI value >= 13% should predict PPV threshold value (13%) with 97% sensitivity and 68% specificity. There was no statistically significant correlation between PPV and CVP. Conclusions PPV is a useful clinical tool to detect occult hypovolaemia and predict cardiovascular response to fluid challenge. Use of PPV is recommended as a part of GDFT in dogs undergoing abdominal procedures.