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Distinct Biomarker Profiles in Ex Vivo T Cell Depletion Graft Manipulation Strategies: CD34 + Selection versus CD3 + /19 + Depletion in Matched Sibling Allogeneic Peripheral Blood Stem Cell Transplantation.

Caroline R Cantilena,Sawa Ito,Xin Tian,Prachi Jain,Fariba Chinian,Prathima Anandi,Keyvan Keyvanfar,Debbie Draper,Eleftheria Koklanaris,Sara Hauffe,Jeanine Superata,David Stroncek,Pawel Muranski,A John Barrett,Minoo Battiwalla

Biology of Blood and Marrow Transplantation（2018）

Cited 2|Views36
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Abstract
•Two different graft manipulation strategies (CD3/19D versus CD34S) were compared.•The cumulative incidence of acute GVHD trended to be higher in CD3/19D.•CD3/19D showed distinct biomarker profiles of high ST2 and immune reconstitution.
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Key words
Ex vivo T cell depletion,Graft manipulation,Biomarkers
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