White matter signal abnormalities in former National Football League players.

Michael L Alosco,Inga K Koerte,Yorghos Tripodis,Megan Mariani,Alicia S Chua,Johnny Jarnagin, Yashar Rahimpour,Christian Puzo, Rose C Healy,Brett Martin,Christine E Chaisson,Robert C Cantu,Rhoda Au,Michael McClean,Ann C McKee,Alexander P Lin,Martha E Shenton,Ronald J Killiany,Robert A Stern

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring（2018）

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摘要

•Repetitive head impact exposure was positively associated with WMSAs in former NFL players.•In former NFL players, greater WMSAs was associated with worse psychomotor speed and executive function.•The pathologies of WMSAs may contribute to the clinical presentation of chronic traumatic encephalopathy.

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关键词

White matter signal abnormalities,White matter hyperintensities,Repetitive head impacts,Chronic traumatic encephalopathy,Alzheimer's disease,Cognitive function,Concussion,Subconcussive

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