Dendritic spines modify action potential back-propagation in a multicompartment neuronal model.

Pyramidal neurons in the brain's neocortex receive, on average, approximately 10,000 synaptic inputs. The majority of these are made onto dendritic spines, which are chemically and electrically isolated from other parts of the neuron. We present an extension to the IBM Neural Tissue Simulator that models details of neuron morphology and the dynamics of intracellular diffusible ions or molecules, a...