Ferritin Overexpression Limits Intracellular Labile Iron and Induces Replication Stress in Lung Cancer Cells

Lipoprotein lipase (LPL) is a gatekeeper for the delivery of fat to tissues in the body. Dietary and endogenous fat circulated as triglycerides in triglyceride-rich lipoproteins. LPL hydrolyses these circulating triglycerides, releasing fatty acids that can be taken up by tissues. The activity of LPL is regulated at many stages and by many different proteins in a tissue specific manner, allowing for the distribution of fatty acid fuel among tissues to be altered according to metabolic conditions. The central role of LPL in lipid delivery also makes it relevant to the pathogenesis of metabolic disease and a potential therapeutic target.