Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control

Isaia Barbieri,Konstantinos Tzelepis,Luca Pandolfini,Junwei Shi,Gonzalo Millán-Zambrano,Samuel C. Robson,Demetrios Aspris,Valentina Migliori,Andrew J. Bannister,Namshik Han,Etienne De Braekeleer,Hannes Ponstingl,Alan Hendrick,Christopher R. Vakoc,George S. Vassiliou,Tony Kouzarides

NATURE（2017）

引用 871|浏览39

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摘要

The methyltransferase METTL3 promotes the leukaemic state in acute myeloid leukaemia (AML) by catalysing the m 6 A RNA modification through its recruitment on the transcription start sites of AML-associated genes.

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关键词

myeloid leukaemia,mettl3,promoter-bound,a-dependent

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