Parachuting psychoactive substances: Pharmacokinetic clues for harm reduction

•Parachuting is a way to ingest psychoactive substances wrapped into cigarette paper.•Parachute acts as sustained-release form when made with a cigarette paper wrapper.•Parachute acts as immediate release form in the presence of alcohol.•This is a message for harm reduction to avoid overdose.•Users must avoid taking another parachute in the absence of an immediate-effect.