Lack of the NAD+-dependent glycerol 3-phosphate dehydrogenase impairs the function of transcription factors Sip4 and Cat8 required for ethanol utilization in Kluyveromyces lactis.

Lucía Mojardín,Montserrat Vega,Fernando Moreno,Hans-Peter Schmitz,Jürgen J Heinisch,Rosaura Rodicio

Fungal Genetics and Biology（2018）

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摘要

•K. lactis glycerol 3-phosphate dehydrogenase is required for growth on ethanol.•KlICL1 and KlMLS1 expressions are down-regulated in the Klgpd1 deletion.•This regulation is mediated by the transcription factors KlSip4 and KlCat8.•Both their promoter binding and activation functions are modulated.•KlGpd1 acts independent of the SNF1 complex in sensing the cells redox state.

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关键词

Carbon stress response,Redox balance,Glyoxylate cycle,SNF1,Peroxisome

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