Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model.
Thrombosis Research（2018）
Key words
Thrombolysis,Fucoidan,PAI-1 binding,Reperfusion,Activating free tPA
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