Vasoconstriction triggered by hydrogen sulfide: Evidence for Na + ,K + ,2Cl - cotransport and L-type Ca 2+ channel-mediated pathway.

Biochemistry and Biophysics Reports(2017)

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摘要
•NaHS induces rat aorta contractions through activation of Na+,K+,2Cl-cotransport and Ca2+ influx via L-type channels.•NaHS increased Na+,K+,2Cl--cotransport activity in smooth muscle cells but not in endothelial cells.•Low doses of NaHS enhanced 45Ca influx in smooth muscle cells, but high doses of NaHS suppressed it.
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关键词
NaHS,NO,CO,H2S,CSE,NaHS,sGC,cGMP,KATP,KCa,EDHF,SMC,VSMC,PE,NKCC,PSS,VSMR,EC,TEA,RAEC,RASMC,COX
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