Perinatal Nicotine Exposure Increases Obesity Susceptibility by Peripheral Leptin Resistance in Adult Female Rat Offspring.

Wan-Xia Zhang,Yin-Ping Li,Jie Fan,Hui-Jian Chen,Gai-Ling Li,Yan-Qiong Ouyang,You-E Yan

Toxicology Letters（2018）

引用 16|浏览29

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摘要

•Perinatal nicotine exposure promotes obesity and metabolic disorders.•Perinatal nicotine exposure induces peripheral leptin resistance in female rats.•The expression of lipolysis genes were affected dominantly in adipose tissue.•The expression of lipogenesis genes were affected dominantly in liver.

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关键词

NIC,JAK2,STAT3,SOCS3,OB-R,GD,isSWAT,igSWAT,gWAT,pWAT,mWAT,CT,TC,TG,HDL-C,LDL-C,NEFA,HOMA-IR,HOMA-β,IPGTT,ITT,PPARα,SREBP1c,PGC1α,FAS,ACC,ATGL,HSL,36B4,HE

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