Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi.

Maura Rojas-Pirela,Daniel J Rigden,Paul A Michels,Ana J Cáceres,Juan Luis Concepción,Wilfredo Quiñones

Molecular and Biochemical Parasitology（2018）

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摘要

•PAS domains are ubiquitous in nature and endow multiple functions to proteins.•Analysis of kinetoplastid genomes revealed PAS domains in various protein kinases.•A PAS-phosphoglycerate kinase (PGK)-like protein was identified in T. cruzi.•The PAS-PGK-like protein contains a PTS1 sequence for import into glycosomes.

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关键词

Per-ARNT-Sim (PAS) domains,Phosphoglycerate kinase like,Glycosome,Cell regulators,PAS domains functions

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