Cellular Calcium Signaling in the Aging Brain.

Remya Chandran,Mantosh Kumar,Lakshmi Kesavan,Reena Sarah Jacob,Sowmya Gunasekaran,Sethu Lakshmi,C Sadasivan,R V Omkumar

Journal of Chemical Neuroanatomy（2019）

引用 40|浏览21

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摘要

•Calcium signaling and homeostasis in the brain show age dependent changes.•Tight regulation of calcium signaling is essential for vital functions of neurons.•Dysfunctions of mitochondria and ER upon aging impair calcium homeostasis and neuronal survival.•Calcium channels like NMDAR, VGCC, IP3R, and RyR undergo age dependent deregulation.•Calcium channels are potential drug targets against neurodegenerative diseases.

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关键词

Aging,Calcium signaling,Neuronal calcium homeostasis,Calcium channels,Aging associated neurodegenerative disease,Oxidative stress,Excitotoxicity

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