Uptake and metabolism of water-borne progesterone by the mussel, Mytilus spp. (Mollusca)
The Journal of Steroid Biochemistry and Molecular Biology（2018）
Abstract
•Mussel’s capacity for uptake of P is very high.•P was transformed into 3β-hydroxy-5α-pregnan-20-one and 5α-pregnane-3β,20β-diol.•The P metabolites identified were free and esterified.•Intact P could not be detected in any fraction of the mussel extract.•Depuration does not reduce the overall progestogenic burden.
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Key words
Mollusc,Bivalve,Steroid metabolism,5α-reductase,3β- hydroxysteroid dehydrogenase,20β-hydroxysteroid dehydrogenase
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