Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.

Tina Fonnes,Hege F Berg,Therese Bredholt,Per-Henrik D Edqvist,Kristina Sortland,Anna Berg,Helga B Salvesen,Lars A Akslen,Henrica M J Werner,Jone Trovik,Ingvild L Tangen,Camilla Krakstad

Gynecologic Oncology（2018）

引用 19|浏览35

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摘要

•ASRGL1 validates as a prognostic marker in a prospective setting.•Low ASRGL1 protein and ASRGL1 mRNA expression predicts poor outcome.•ASRGL1 expression has independent impact on survival.•Precursor lesions express high ASRGL1 levels.•The majority of metastases have low ASRGL1 expression.

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关键词

Endometrial carcinoma,Hysterectomy,Prognostic,Biomarker,ASRGL1

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