Systematic literature review of health-related quality of life in locally-advanced non-small cell lung cancer: Has it yet become state-of-the-art?

•Review of health-related quality of life (HRQoL) in locally advanced NSCLC trials.•Evaluation of HRQoL in this particular patient population remains scarce.•HRQoL data could help to forecast and assess relative risk and benefit of therapy.•Measuring, reporting and statistical analysis of HRQoL data remains challenging.