Tissue Transport Affects How Treatment Scheduling Increases the Efficacy of Chemotherapeutic Drugs.

•A tissue-transport model was developed to optimize chemotherapeutic schedules.•Increasing doses is most effective for drugs with intermediary cell binding rates.•Strong and weak binding drugs do not benefit as much from increasing doses.•Many doses are best for drugs with fast diffusivity and weak cell binding.•One dose is best for drugs with slow diffusivity or strong cell binding.