Antibiotic prophylaxis and infection prevention for endoscopic endonasal skull base surgery: Our protocol, results, and review of the literature.

•Endoscopic endonasal skull base surgery (EESBS) provides minimally invasive corridors to intracranial lesions.•The use of antibiotic prophylaxis for patients undergoing EESBS is quite variable.•Our antibiotic prophylaxis protocol led to low rates of postoperative meningitis.•Dural reconstruction has added to low rates of CSF leaks and infection.•Possible changes to our protocol would be to decrease the duration of prophylaxis.