Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring.
Reproductive Toxicology（2017）
Abstract
•PCI increased expression of lung structure-associated genes in offspring.•Upregulation of structural genes contributes to pulmonary interstitial thickness.•Destroyed lung structure results in susceptibility of offspring to inflammation.
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Key words
PCI,IUGR,LPS,GD,PND,HE,GAPDH,IL,TNF,TGF
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