A CRISPR screen identifies a pathway required for paraquat-induced cell death

Colleen R Reczek,Kıvanç Birsoy,Hyewon Kong,Inmaculada Martínez-Reyes,Tim Wang,Peng Gao,David M Sabatini,Navdeep S Chandel

Nature Chemical Biology（2017）

引用 112|浏览2

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摘要

positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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关键词

crispr screen,cell death,pathway,paraquat-induced

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