High mobility group box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy.

Teresa Ravizza,Gaetano Terrone,Alessia Salamone,Federica Frigerio,Silvia Balosso,Daniel J Antoine,Annamaria Vezzani

Brain, Behavior, and Immunity（2018）

引用 91|浏览44

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摘要

•HMGB1 is released in epileptic brain.•Disulfide HMGB1 contributes to seizure pathogenesis and comorbidites.•TLR4 mediate HMGB1’s effects in epilepsy.•HMGB1 isoforms may serve as disease biomarkers.•Anti-HMGB1 drugs affect epileptogenesis and reduce seizures and comorbidities.

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关键词

Sterile inflammation,Damage-associated molecular pattern,Toll-like receptors,Epileptogenesis,Seizures,Comorbidities,Glia

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