Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import

Ireos Filipuzzi,Janos Steffen, Mitchel Germain, Laetitia Goepfert, Michael A Conti,Christoph Potting, Raffaele Cerino,Martin Pfeifer,Philipp Krastel,Dominic Hoepfner,Julie Bastien,Carla M Koehler,Stephen B Helliwell

NATURE CHEMICAL BIOLOGY（2017）

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摘要

The natural product stendomycin is a first-in-class inhibitor of the TIM23 mitochondrial translocon in yeast and mammalian cells that helped reveal that the TIM23 complex does not regulate transport of the autophagy regulator PINK1.

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关键词

Membrane trafficking,Natural products,Target identification,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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