NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR

Hui Feng,Erik M Lenarcic,Daisuke Yamane,Eliane Wauthier,Jinyao Mo,Haitao Guo,David R McGivern,Olga González-López,Ichiro Misumi,Lola M Reid,Jason K Whitmire,Jenny P-Y Ting,Joseph A Duncan,Nathaniel J Moorman,Stanley M Lemon

NATURE IMMUNOLOGY（2017）

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摘要

NLR proteins contribute to antiviral immune responses. Lemon and colleagues show that NLRX1 promotes antiviral responses in hepatocytes by competing with the kinase PKR for viral double-stranded RNA, which allows accumulation of the transcription factor IRF1 for early control of viral replication.

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关键词

Acute inflammation,Innate immunity,Virology,Biomedicine,general,Immunology,Infectious Diseases

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