Comparison of diglycolic acid exposure to human proximal tubule cells in vitro and rat kidneys in vivo .

Miriam E Mossoba,Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop,Zachary Keltner,Vanessa Topping,Thomas Black,Nicholas Olejnik,Ana Depina, Kathleen Belgrave,Jessica Sprando, Joyce Njorge,Thomas J Flynn,Paddy L Wiesenfeld,Robert L Sprando

Toxicology Reports（2017）

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摘要

•Diglycolic acid (DGA) is an indirect food additive.•DGA was tested for renal cell toxicity in vitro using HK-2 cells.•Evaluation of toxicity included cellular and mitochondrial effects.•In vitro data are highly concordant with in vivo outcomes.

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关键词

DGA,ROS,MMP,KIM-1

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