Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
NATURE(2017)
Abstract
The growth of adult and paediatric brain tumours depends on a microenvironmental signalling pathway involving the activity-regulated secretion of neuroligin-3 (NLGN3) from normal neurons and oligodendrocyte precursor cells, highlighting the potential of NLGN3 as a therapeutic target.
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Key words
Cellular neuroscience,CNS cancer,Mechanisms of disease,Science,Humanities and Social Sciences,multidisciplinary
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