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Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

Humsa S. Venkatesh,Lydia T. Tam,Pamelyn J. Woo,James Lennon,Surya Nagaraja,Shawn M. Gillespie,Jing Ni,Damien Y. Duveau,Patrick J. Morris,Jean J. Zhao,Craig J. Thomas,Michelle Monje

NATURE（2017）

Cited 394|Views50
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Abstract
The growth of adult and paediatric brain tumours depends on a microenvironmental signalling pathway involving the activity-regulated secretion of neuroligin-3 (NLGN3) from normal neurons and oligodendrocyte precursor cells, highlighting the potential of NLGN3 as a therapeutic target.
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Key words
Cellular neuroscience,CNS cancer,Mechanisms of disease,Science,Humanities and Social Sciences,multidisciplinary
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