Adult human dermal fibroblasts exposed to nanosecond electrical pulses exhibit genetic biomarkers of mechanical stress.

Caleb C Roth,Randolph D Glickman,Stacey L Martens,Ibtissam Echchgadda,Hope T Beier,Ronald A Barnes,Bennett L Ibey

Biochemistry and Biophysics Reports（2017）

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摘要

•Global gene expression analysis was performed on primary cells exposed to nsEP.•The bioeffects of nsEP on adult human dermal fibroblasts were investigated.•Microarray analysis suggests nsEP imparts a mechanical stress on cells.•FOS, NR4A2, ITPKB, KLHL24, and SOD2 were upregulated in response to nsEP.

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关键词

Adult human dermal fibroblasts,Mechanical stress,Microarray,Nanosecond electrical pulse,FOS,ITPKB

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