A robust quantitative near infrared modeling approach for blend monitoring
Journal of Pharmaceutical and Biomedical Analysis(2018)
摘要
•A Near-infrared calibration strategy was developed for pharmaceutical blend monitoring in which only gram scale material was required to monitor kilogram scale blending process.•Quantitative Near-Infrared spectroscopy models for blend monitoring developed on small-scale with same optical setup and no blender showed similar performance to models built on larger scale with the blender.•Density control on small-scale showed to have significant effect when modeling on larger scale as the prediction bias increased when density was not controlled in the small-scale calibration dataset.
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关键词
Near infrared spectroscopy,Pharmaceutical blend homogeneity,Calibration design,Partial least squares
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