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Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.

Wei Zhang,Rui Wei,Lin Zhang,Yang Tan,Chuanyun Qian

Neuroscience（2017）

Cited 112|Views4
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Abstract
•Cerebral I/R can result in decreased SIRT6 expression.•SIRT6 can ameliorate brain damage.•SIRT6 can activate NRF2 and reduce oxidative stress.•NRF2 Knockout can exacerbate brain damage.•NRF2 Knockout can abolish the neuroprotective effects of SIRT6 in cerebral I/R.
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ARE,DCF,HO-1,I/R,LDH,MCAO,MDA,OGD/R,ROS,SIRT,SOD,TUNEL
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