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Gentamicin synergises with azoles against drug-resistant Candida albicans

Mengjiao Lu,Cuixiang Yu,Xueyan Cui,Jinyi Shi,Lei Yuan,Shujuan Sun

International Journal of Antimicrobial Agents（2018）

Cited 37|Views4
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Abstract
•Gentamicin (GM) synergises with azoles against planktonic cells of resistant Candida albicans.•GM synergises with fluconazole (FLC) against pre-formed biofilms of C. albicans.•GM enhanced the in vivo efficacy of FLC against resistant C. albicans.•GM suppresses the efflux pump of resistant C. albicans.•GM + FLC reduces phospholipase activity of resistant C. albicans.
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Key words
Gentamicin,Azoles,Synergy,Drug-resistant Candida albicans,Galleria mellonella model
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