Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma

Phillips Y Huang,Eve Kandyba,Arnaud Jabouille,Jonas Sjolund,Atul Kumar,Kyle Halliwill,Melissa McCreery,Reyno DelRosario,Hio Chung Kang, Christine E Wong,Jost Seibler, Vincent Beuger,Maurizio Pellegrino,Adam Sciambi,Dennis J Eastburn,Allan Balmain

NATURE GENETICS（2017）

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摘要

Lineage-tracing experiments in the mouse show that Lgr6 , but not Lgr5 , functions as a cancer stem marker in skin squamous cell carcinomas (SCCs). The authors also show that Lgr6 -knockout mice are predisposed to SCC development, through a mechanism that includes compensatory upregulation of Lgr5 .

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关键词

Squamous cell carcinoma

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