d-Allulose enhances postprandial fat oxidation in healthy humans.

•d-Allulose, a C-3 epimer of d-fructose, decreases body weight and abdominal adipose tissue weight in animals probably through enhanced energy expenditure.•We examined the effects of a single ingestion of d-allulose on postprandial energy metabolism in healthy humans.•d-Allulose enhanced postprandial fat oxidation and decreased carbohydrate oxidation.•To our knowledge, this is the first report showing that d-allulose enhances energy metabolism in healthy humans at a low dose of 5 g.•d-Allulose could be a novel sweetener to control and maintain healthy body weight.