Hypoxia stimulates proliferation of rat neural stem/progenitor cells by regulating mir-21: an in vitro study.

Rui Chen, Yanmei Liu,Qian Su,Yang Yang,Li Wang,Shuyun Ma,Jiajia Yan,Fangfang Xue,Jianjun Wang

Neuroscience Letters（2017）

引用 12|浏览10

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摘要

•Hypoxia treatment promotes the expression of miR-21 in cultured NSPCs.•miR-21 promotes the proliferation of NSPCs and enhances the expression of cyclin D1 after hypoxia treatment.•miR-21 impacts on cultured NSPCs via activation of AKT signaling pathway.

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关键词

NSPCs,BrdU,CNS,SGZ,DG,SVZ,hASCs,EGF,bFGF,PI,PIP3

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