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Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study

Sandra De Jonghe,Mark D. Johnson,Rao N.V.S. Mamidi,Petra Vinken,Bianca Feyen,Godelieve Lammens,Jim Proctor

Chemico-Biological Interactions（2017）

Cited 4|Views23
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Abstract
During preclinical development of canagliflozin, an SGLT2 inhibitor, treatment-related pheochromocytomas, renal tubular tumors (RTT), and testicular Leydig cell tumors were reported in the 2-year rat toxicology study.
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Key words
Canagliflozin,SGLT2 inhibitor,SGLT1 inhibitor,Kidney tumors,Pheochromocytomas,Adrenal medullary hyperplasia,Carbohydrate malabsorption
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