Gene Modified T Cell Therapies for Hematological Malignancies.
Hematology/Oncology Clinics of North America(2017)
摘要
This article focuses on clinical applications of T cells transduced to express recombinant T cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address GvHD and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.
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关键词
Gene therapy,Gene editing,Adoptive immunotherapy,T cell receptor,Chimeric antigen receptor,Lentiviral vectors,Leukemia,Lymphoma
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