Effect of lentivirus-mediated gene silencing, targeting toll-like receptor 2, on corneal allograft transplantation in rats.

Lang Bai,Weiyi Liang,Minting Chen,Yacouba Cissé,Jing Liu,Yaru Su,Jian Yu,Qiong Liu

Molecular Immunology（2017）

引用 7|浏览15

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摘要

•TLR2/MyD88 signaling pathway may play a critical role in cornea transplantation.•TLR2 siRNA could safely and effectively suppress TLR2 expression on cornea.•Gene silencing targeting TLR2 could attenuate rejection after keratoplasty.

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关键词

Lentiviral vector,Corneal transplantation,Toll-like receptor 2,Myeloid differentiation primary response gene 88

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