Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Wei Zhao,Asif Rasheed,Emmi Tikkanen,Jung-Jin Lee,Adam S Butterworth,Joanna M M Howson,Themistocles L Assimes,Rajiv Chowdhury,Marju Orho-Melander,Scott Damrauer,Aeron Small,Senay Asma,Minako Imamura, Toshimasa Yamauch,John C Chambers,Peng Chen,Bishwa R Sapkota,Nabi Shah, Sehrish Jabeen,Praveen Surendran,Yingchang Lu,Weihua Zhang,Atif Imran,Shahid Abbas,Faisal Majeed,Kevin Trindade,Nadeem Qamar,Nadeem Hayyat Mallick,Zia Yaqoob,Tahir Saghir,Syed Nadeem Hasan Rizvi,Anis Memon,Syed Zahed Rasheed,Fazal-ur-Rehman Memon,Khalid Mehmood,Naveeduddin Ahmed,Irshad Hussain Qureshi, Tanveer-us-Salam, Wasim Iqbal,Uzma Malik,Narinder Mehra,Jane Z Kuo,Wayne H-H Sheu,Xiuqing Guo,Chao A Hsiung,Jyh-Ming J Juang,Kent D Taylor,Yi-Jen Hung,Wen-Jane Lee,Thomas Quertermous,I-Te Lee,Chih-Cheng Hsu,Erwin P Bottinger,Sarju Ralhan,Yik Ying Teo,Tzung-Dau Wang,Dewan S Alam,Emanuele Di Angelantonio, Steve Epstein,Sune F Nielsen,Børge G Nordestgaard,Anne Tybjaerg-Hansen,Robin Young,Marianne Benn,Ruth Frikke-Schmidt,Pia R Kamstrup,J Wouter Jukema,Naveed Sattar,Roelof Smit,Ren-Hua Chung,Kae-Woei Liang,Sonia Anand,Dharambir K Sanghera,Samuli Ripatti,Ruth J F Loos,Jaspal S Kooner,E Shyong Tai,Jerome I Rotter,Yii-Der Ida Chen,Philippe Frossard,Shiro Maeda,Takashi Kadowaki,Muredach Reilly,Guillaume Pare,Olle Melander,Veikko Salomaa,Daniel J Rader,John Danesh,Benjamin F Voight,Danish Saleheen

NATURE GENETICS（2017）

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摘要

Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci are also associated with CHD and that greater genetic risk of T2D increases risk of CHD.

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关键词

Cardiovascular diseases,Genetics,Genomics,Type 2 diabetes,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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